Sunday, 29 June 2014

Basket trials

A new type of trials that was mentioned a number of times at ASCO- BASKET trials.

The idea behind a basket trial is to match a patient whose tumor shows a specific mutation- like BRAF or NRAS- to a drug that is know to work on that mutation. So a Melanoma patient with a BRAF mutation could be on that trial as well as a colon cancer patient with a BRAF mutation.

You can find an article on the topic here:

This type of trial will become increasingly important the more we learn about the genetic make-up of tumours and as the article says:

'Though randomized clinical trials are the preferred gold standard for FDA approval, the design is often not feasible in a timely manner for rare mutations and patients with rapidly advancing malignancies.  - See more at:'

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